Clearance of persistent SARS-CoV-2 associates with increased neutralizing antibodies in advanced HIV disease post-ART initiation
by Alex Sigal et alEvolution and neutralization escape of the SARS-CoV-2 BA.2.86 subvariant
by Alex Sigal et alNon-pharmaceutical interventions and the emergence of pathogen variants
by Ben Ashby, Cameron A Smith, Robin N ThompsonGenetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil
by Natalia Fintelman-Rodrigues et al.The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented.